The GENIORS Horizon 2020 project focuses on improving current recycling of spent nuclear fuel and future multiple recycling strategies to be implemented in the 4th generation of reactors expected to enter operation by 2030. Through sound research and an innovative approach, GENIORS is expected to provide the EU with science-based strategies for nuclear fuel management and contribute significantly to its energy independence. In the longer term, the project’s results will facilitate radioactive waste management by reducing its volume and radiotoxicity, and support a more efficient utilisation of natural resources.